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Summary of Awards

African American Advisory Committee	Scripps Research Institute
Beckman Research Institute of the City of Hope	Stanford University
California Institute of Technology	Sidney Kimmel Cancer Center
California Pacific Medical Center Research Institute	The Burnham Institute
Cedars-Sinai Medical Center	University of California, Berkeley
Harbor-UCLA Research and Education Institute	University of California, Davis
Kaiser Foundation Research Institute	University of California, Irvine
La Jolla Institute for Molecular Medicine	University of California, Los Angeles
Lawrence Berkeley National Laboratory	University of California, San Diego
Northern California Cancer Center	University of California, San Francisco
Public Health Institute	University of Southern California
Salk Institute for Biological Studies	Young Moms with Breast Cancer

African American Advisory Committee

INSTITUTION / PI / TITLE	TAX	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Priscilla Banks African American Women and Breast Cancer: What Works?	X	1.5	Collaborative Award

Beckman Research Institute of the City of Hope

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Jennifer Murray Regulation of SXR and Drug Resistance in Breast Cancer	2.0	$42,784	$0	$42,784

California Institute of Technology

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Cheryl Van Buskirk Analysis of EGFR Transcript Splicing in C. Elegans	2.0	$80,000	$6,400	$86,400

California Pacific Medical Center Research Institute

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Shanaz Dairkee Infinite Expansion of Breast Tumor Samples in Culture	2.0	$80,000	$6,400	$86,400
Robert Debs Molecular Pathogenesis of Metastatic Breast Cancer	2.0	$80,000	$6,400	$86,400
Subtotal		$400,000	$222,800	$622,800

Cedars-Sinai Medical Center

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Shikha Bose The Role of PTEN in Progression of Ductal Carcinoma in situ	2.0	$200,000	$106,000	$306,000

Harbor-UCLA Research and Education Institute

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Rowan Chlebowski Weight Loss in Public Hospital Breast Cancer Patients	1.5	$100,000	$40,941	$140,941

Kaiser Foundation Research Institute

INSTITUTION / PI / TITLE	TAX	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Carol Somkin African American Women and Breast Cancer: What Works?	X	1.5	$99,505	$32,550	$132,055

La Jolla Institute for Molecular Medicine

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Longchuan Chen Defining a Role for Endothelial Precursor Cells in Breast	1.0	$103,094	$96,080	$199,174

Lawrence Berkeley National Laboratory

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Jamie Bascom Relating Epimorphin and Progesterone-Mediated Morphogenesis	1.0	$23,825	$0	$23,825
Albert Davalos Does the BLM Gene Co-regulate BRCA1 in DNA Damage Response?	2.0	$80,000	$672	$80,672
David Gilley Studies of Telomere Capping Dysfunction in Breast Cancer	3.0	$300,000	$202,975	$502,975
Terumi Kohwi-Shigematsu Global Gene Regulation by SATB1 in Metastatic Breast Cancer	1.0	$98,949	$62,564	$161,513
Ana Krtolica Aging, Mutations, and Breast Carcinogenesis	3.0	$276,580	$172,304	$448,884
Saira Mian Statistical Techniques for Breast Biology and Cancer Research		$453,613	340,755	$794,368
Carlos Ortiz de Solorzano Three-Dimensional Modeling of Breast Cancer Progression	2.0	$200,000	$136,328	$336,328
Aylin Rizki Effect of Breast Cell Environment on Repair of DNA Damage	2.0	$80,000	$672	$80,672
Christine Hartmann Siantar New Imager to Improve Specificity in Breast Cancer Detection	1.5	$113,462	$100,000	$213,462
Kai Vetter New Imager to Improve Specificity in Breast Cancer Detection	1.5	Collaborative Award
Subtotal		$1,612,967	$1,029,732	$2,642,699

Northern California Cancer Center

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Sally Glaser Immune-Function Genes and Race Differences in Breast Cancer	2.0	$149,991	$53,397	$203,388

Public Health Institute

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Barbara Cohn Can Placenta Factors Explain Race Patterns of Breast Cancer?	0.8	$73,154	$13,021	$86,175

Salk Institute for Biological Studies

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Yan Xia BRCA-1-dependent Ubiquitin Ligase Activity in Breast Cancer	2.0	$80,000	$6,400	$86,400

Scripps Research Institute

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Benjamin Cravatt Profiling Enzyme Activities in Models of Human Breast Cancer	2.0	$199,518	$169,990	$369,508
Arul Joseph Method to Profile Active Metalloprotoeases in Breast Cancer	2.0	$80,000	$6,400	$86,400
Beatriz Maroto DNA Damage Response Pathways in Breast Cancer Cells	2.0	$80,000	$6,400	$86,400
Vito Quaranta MMP-Directed Synthesis of Invasive Breast Cancer Blockers	1.0	$73,555	$62,669	$136,224
Subtotal		$433,073	$245,459	$678,532

Sidney Kimmel Cancer Center

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Francisco Javier Piedrafita Retinoids in Combination Therapies against Breast Cancer	2.0	$200,000	$196,800	$396,800
Jan Schnitzer Identifying Accessible Targets in Human Breast Tumors	1.5	$250,000	$246,000	$496,000
Subtotal		$450,000	$442,800	$892,800

Stanford University

INSTITUTION / PI / TITLE	TAX	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Steven Artandi Understanding Telomere Dynamics in the Breast		3.0	$423,398	$252,293	$675,691
Karlene Cimprich Identifying sources of Genomic Instability in Breast Cancer		1.5	$75,000	$43,657	$118,657
Bradley Ekstrand Using Microarrays to Estimate Breast Cancer Risk		2.0	$80,000	$6,400	$86,400
James Ford Genetic Alterations in MRI Screen-Detected Breast Lesions		1.5	$100,000	$57,000	$157,000
Stefanie Jeffrey Breast Stromal Genes Act as Early Markers of Malignancy	X	3.0	$249,999	$142,499	$392,498
Patrick Lupardus Regulation of the Rad1 Checkpoint Complex in Breast Cancer		2.0	$60,000	$0	$60,000
Slyvia Plevritis Genetic Alterations in MRI Screen-Detected Breast Lesions		1.5	Collaborative Award
Jonathan Pollack Locating Novel Breast Cancer Genes using DNA Microarrays		3.0	$299,870	$170,926	$470,796
Lynn Westphal Chemotherapy-Induced Ovarian Damage: Prevention and Impact		1.5	$30,531	$21,824	$52,355
Subtotal			$1,310,091	$703,306	$2,013,397

The Burnham Institute

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Kelly Boatright Alterations in the Separase/Securin Balance in Breast Cancer	2.0	$60,000	$0	$60,000
Nathalie Bruey-Sedano Cell-Killing Effect of Orphan Receptor TR3 in Breast Cancer	2.0	$80,000	$6,400	$86,400
Hee Kwang Choi Rac/STAT5 Signaling	2.0	$80,000	$6,400	$86,400
Marcia Dawson Novel Retinoids with Enhanced Anti-Breast Tumor Efficacy	2.0	$200,000	$184,000	$384,000
Kathryn Ely A Novel Anti-estrogen Resistance Mechanism in Breast Cancer	1.5	$75,000	$69,000	$144,000
Shi Huang Steroid Receptor Coactivators in Mammary Gland Development	2.0	$195,020	$185,220	$380,240
Lynn Knowles Fatty Acid Synthase and Breast Cancer	2.0	$80,000	$6,400	$86,400
Sergei Malkhosyan Cloning of the X Chromosome's Putative Tumor Suppressor Gene	2.0	$147,000	$141,000	$288,000
Francesca Marassi Structure and Function of the Bax Apoptosis Regulator	2.0	$147,000	$141,000	$288,000
John Reed PPAR Modulators as Apoptosis	2.0	$242,382	$222,991	$465,373
Xiao-Kun Zhang TR3-based Peptides for Apoptosis in Breast Cancer	2.0	$200,000	$184,000	$384,000
Subtotal		$1,484,602	$1,168,211	$2,652,813

University of California, Berkeley

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Satyabrata Nandi Breast Cancer Prevention with Estrogen	3.0	$812,340	$0	$812,340

University of California, Davis

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Gerald DeNardo New Imager to Improve Specificity in Breast Cancer Detection	1.5	Collaborative Award
Navdeep Dhillon Cyclin E Affects Growth Arrest in Breast Cancer Cells	2.0	$50,386	$0	$50,386
Martin Privalsky Regulation of Estrogen Response by Corepressors	2.0	$149,942	$0	$149,942
Subtotal		$200,328	$0	$200,328

University of California, Irvine

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Catherine Blake Using Scientific Text to Identify Breast Cancer Risk Factors	1.0	$29,136	$0	$29,136
Michael Samoszuk Clotting Breast Cancer	1.0	$98,986	$0	$98,986
Subtotal		$128,122	$0	$128,122

University of California, Los Angeles

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Carolyn Crandall Impact of Breast Cancer and its Therapy on Bone Density	3.0	$300,000	$0	$300,000
Jill Mitchell Constructed Meaning and Stress in Breast Cancer Experience	2.0	$64,087	$0	$64,087
Cindy Wilson The Importance of Growth Inhibitory Signals in Normal Breast	2.0	$150,000	$0	$150,000
Subtotal		$514,087	$0	$514,087

University of California, San Diego

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Gerry Boss Prognostic Value of Ras Activation in Breast Cancer	3.0	Collaborative Award
Anne Wallace Prognostic Value of Ras Activation in Breast Cancer	3.0	$499,796	$0	$499,796
Subtotal		$499,796	$0	$499,796

University of California, San Francisco

INSTITUTION / PI / TITLE	TAX	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Christine Case Lo Drug Dose Tailoring Based on Patient-Specific Factors		2.0	$50,572$0		$50,572
Aubri Charboneau HOX Transcriptional Regulation of Angiogenesis		2.0	$80,000$0		$80,000
Nicola Clegg Novel Ligands as Probes of Estrogen Receptor Signaling		2.0	$50,941$0		$50,941
Colin Collins The Detailed Structure of a Model Breast Cancer Genome		2.0	$194,840$0		$194,840
Steven Cummings Compositional Breast Density as a Risk Factor		1.5	Collaborative Award
Mikala Egeblad The Role of Matrix Metalloproteinase 13 in Breast Cancer		2.0	$80,000	$0	$80,000
Karla Kerlikowske Compositional Breast Density as a Risk Factor		1.5	$100,000	$0	$100,000
Dale Leitman Identification and Prognostic Value of ERß in Breast Cancer		2.0	$150,000	$0	$150,000
Richard Price, Jr. Targeting Estrogen Receptors to Mouse Mammary Epithelium		2.0	$80,000	$0	$80,000
Hope Rugo Chemotherapy-Induced Ovarian Damage: Prevention and Impact		1.5	$82,479	$0	$82,479
John Shepherd Compositional Breast Density as a Risk Factor		1.5	Collaborative Award
Thea Tlsty Breast Stromal Genes Act as Early markers of Malignancy	X	3.0	$249,999	$0	$249,999
Jack Youngren Potential New Drug Therapy for Breast Cancer		2.0	$199,848	$0	$199,848
Subtotal			$1,318,679	$0	$1,318,679

University of Southern California

INSTITUTION / PI / TITLE	TAX	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Elizabeth Lillie The Androgen Receptor and Mammographic Density		2.0	$59,998		$59,998
Malcolm Pike Fiber, Estrogen and Breast Cancer in Mexican American Women	X	1.5	$98,275	$61,422	$159,697
Ronald Ross USC/NCCC Breast Cancer Research Training Program		3.0	$249,720	$19,978	$269,698
Wei Wang Androgen Receptor Gene and PSA Gene in Breast Cancer Risk		2.0	$60,000	$0	$60,000
Subtotal			$467,993	$81,400	$549,393

Young Moms with Breast Cancer

INSTITUTION / PI / TITLE	DURATION	DIRECT COST	INDIRECT COST	TOTAL
Lucy Berlin Chemotherapy-Induced Ovarian Damage: Prevention and Impact	1.5	Collaborative Award

Total Awards

$10,553,592

$4,255,511

$14,809,103

SUPPLEMENTS

University of California, Irvine

INSTITUTION / PI / TITLE	TAX	DURATION	TOTAL
Sora Tanjasiri A Network-Based Intervention for Chamorros in Southern CA	X	3.0	$19,900

Stanford University

INSTITUTION / PI / TITLE	TAX	DURATION	TOTAL
David Spiegel Does a Peer Navigator Improve Quality of Life at Diagnosis?	X	3.0	Collaborative Supplement

WomenCARE

INSTITUTION / PI / TITLE	TAX	DURATION	TOTAL
Caroline Bliss-Isberg Does a Peer Navigator Improve Quality of Life at Diagnosis?	X	3.0	$20,000

University of California, Los Angeles

INSTITUTION / PI / TITLE	TAX	DURATION	TOTAL
Rose Maly Determinants of Breast Cancer Treatment in the Underserved	X	3.0	$40,000
Katherine Kahn The Impact of Structure on Quality of Breast Cancer Care	X	3.0	$40,000
Subtotal			$80,000

University of Southern California

INSTITUTION / PI / TITLE	TAX	DURATION	TOTAL
Michael Press HER-s/neu Gene Variations and Breast Cancer Risk	X	3.0	$40,000

University of California, Davis

INSTITUTION / PI / TITLE	TAX	TOTAL
Colleen Sweeney Pathway-Specific Gene Expression in Breast Cancer Cells	X	$40,000

Total Supplements

$199,900