Call for Applications — Cycle 17—2011

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Table of Contents

New for 2011!
CBCRP Background
CRCRP Revised Research Funding Priorities for 2011
Letter of Intent (LOI) and Application Deadlines
Where to Start—Overview
Advocacy Involvement and Sensitivity to Advocacy Issues
CBCRP’s Research Priority Issues
The Community Impact of Breast Cancer: the social context
Etiology and Prevention: finding the underlying causes
Biology of the Breast Cell: the basic science of the disease
Detection, Prognosis, and Treatment: delivering clinical solutions
CBCRP’s Award Types
1. Community Research Collaboration Awards
2. Translational Research Award
3. Innovative, Developmental, and Exploratory Awards (IDEA)
4. CBCRP Conference Awards
5. Special Research Initiatives
6. Health Policy Initiative
General Information

New for 2011!

• IDEA and Translational Research Awards require submission of a Letter of Intent (LOI).
• IDEA–competitive renewals are available in 2011 for the last time. Only IDEA grants originating in 2009 (Cycle 15) are eligible to apply.
• The CBCRP is no longer offering Dissertation Awards and Postdoctoral Fellowships.
• CBCRP Conference Awards have one submission deadline.

CBCRP Background

The California Breast Cancer Research Program (CBCRP) is pleased to present our 2011 Cycle 17 Call for Applications. We expect to have available at least $9.6 million to award new grants beginning July 1, 2011. The CBCRP funds research only in California.

The mission of the CBCRP is to eliminate breast cancer by leading innovation in research, communication, and collaboration in the California scientific and lay communities.

In 1993, California breast cancer activists joined forces with scientists, clinicians, state legislators, and University of California officials to catapult the state into national leadership for breast cancer research. The activists, most of them women who had survived or currently had breast cancer, were impatient with the slow pace of progress against the disease. With their allies, they wrote and won passage of statewide legislation to push breast cancer research in new, creative directions. The California Breast Cancer Act, sponsored by Assemblywoman Barbara Friedman, increased the tobacco tax by 2¢ per pack, with 45 percent of the revenue going to the CBCRP. We also receive support from donations to a designated line on State income tax returns and private contributions. The CBCRP has provided more than $213 million in research funds since 1995.

CRCRP Revised Research Funding Priorities for 2011

The CBCRP’s council underwent an intensive and data-driven priority-setting process and carefully considered the Program’s goals, achievements, and future research opportunities. As a result, they created a strategic plan for the overall allocation of research funds for the period from 2011-2015. The projected funding distribution is shown in the table below. Total CBCRP research funding for the 2010-2011 year is anticipated to be $9.6M.

In addition, the following changes will be implemented:

• Institute a Letter of Intent process to screen potential submissions for relevance. This will reduce the burden on applicants and maintain an adequate success rate, allowing us to attract the highest quality and most responsive projects.
• Discontinue IDEA-competitive renewal funding after the current cycle; the award will be offered this year only to allow existing IDEA investigators to compete for additional support, as was promised when these awards were initiated.
• Set-aside $2M/yr for community collaboration awards to maintain this unique CBCRP funding mechanism that supports research that is specific to California needs.
• Set aside $50K a year for conference awards.
• Devote 50% of our research budget to continued our program directed Special Research Initiatives on the environmental causes of breast cancer, the disparities/inequities in the incidence and mortality of breast cancer, and expand it to address the topic of breast cancer prevention, specifically:
  • Population-level interventions (including policy research) on known and suspected risk factors and protective measures;
  • Targeted interventions for high-risk individuals including new methods for identifying or assessing risk. The CBCRP has set aside $150,000/year to implement a Health Policy Initiative that utilizes a rapid response mechanism to fund breast cancer policy research.

* Contact SRI@cabreastcancer.org to be included on the mailing list for SRI funding announcements.
** Contact healthpolicy@cabreastcancer.org to be included on the mailing list for Health Policy Initiative funding announcements.

Letter of Intent (LOI) and Application Deadlines

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Applications and LOIs, except the CRC pre-application research plan, must be submitted online through Altum proposalCENTRAL (https://proposalcentral.altum.com/). Forms and instructions for LOIs will be available by September 1 on both proposalCENTRAL and CBCRP’s website.

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Please note:
► CBCRP has only one funding cycle per year with the submission deadlines listed in the Table below. 
► The IDEA, Translational Research Award, and IDEA–competitive renewal applications require a “letter of intent” (LOI) that must be approved prior to submitting a full application.

* Contact conferenceaward@cabreastcancer.org for information on Conference Awards.
^ Optional, only if the applicants wish to receive feedback prior to a full submission.

Where to Start—Overview

Before applying to the CBCRP for grant funding, you should consider our program’s background, funding philosophy, and existing portfolio. Our focus is specifically targeted to breast cancer, so researchers outside this field should cultivate collaborations or develop preliminary data in breast cancer prior to applying.  Make sure our priority issues and award types presented in this booklet match your research interests and type of project.

We encourage applicants to contact the CBCRP Research Administrators at 888-313-2277 to discuss any questions about the selection of priority issue and award type.

Review the CBCRP-funded portfolio on our Web site (www.cabreastcancer.org/research/) to get a feel for our funding interests. We are interested in funding novel topics not yet represented in the CBCRP or other agencies portfolios. It is especially important for applicants who have received prior CBCRP funding to distinguish a newly submitted project from past projects. We also encourage you to inspect your topic area on the International Cancer Research Portfolio (ICRP) Web site: www.cancerportfolio.org/

Applicants should carefully consider our evaluation and funding process. Applications will be reviewed in a 3-step process that includes:

• LOI review by CBCRP council and invitation to apply to those most responsive to program award type, research priority issue (topic), and other criteria (advocacy involvement in the research, critical path, etc.).
• Application peer review by out-of-state researchers and advocates to rate applications on scientific merit and provide written feedback.
• Final programmatic review by council for a funding recommendation.

It is a combination of scientific merit and programmatic responsiveness that determines a decision to offer funding. Applicants will receive a detailed peer review evaluation summary with key points from the review committee discussion and information on the programmatic review/funding decision.

Advocacy Involvement and Sensitivity to Advocacy Issues

The CBCRP was established through the efforts and dreams of breast cancer advocates, and we are deeply committed to advocate involvement in all aspects of our portfolio and our program. Advocates from outside California participate in the peer review of every application, and advocates represent approximately one third of the CBCRP council membership. The CBCRP believes that research projects benefit by being directly informed by the experiences and knowledge of patient-survivors. Therefore, we expect breast cancer and community health advocates to be actively involved in the research we fund.  Applicants are expected to work with advocates and advocacy organizations and LOIs/applications are evaluated on the extent to which advocates are involved in the project. 

CBCRP staff can assist you with meeting this requirement.  Here are some suggestions:

• Contact an advocate/activist group in your area to discuss your research project with them and receive feedback and suggestions.
• Use advocates/activists as a resource to find the “human link” between your project and their experience as breast cancer survivors to better appreciate the social/community issues related to breast cancer.
• Visit advocate/activist displays and posters at cancer meetings (e.g., San Antonio Breast Cancer Symposium) to discuss your research interests. Many advocates welcome interactions with researchers.
• Examine the literature and Web sites of advocate/activist organizations to get a sense of their social/research concerns and needs.
• Obtain a “letter of collaboration” from an advocate/activist organization describing their role in your project.

Examples of advocacy concerns and human issues can be sourced through web sites, such as:

• http://www.networkofstrength.org/    Breast Cancer Network of Strength
• http://www.natlbcc.org/ National Breast Cancer Coalition
• http://www.bcaction.org/  Breast Cancer Action
• http://www.breastcancerfund.org  The Breast Cancer Fund
• http://www.komen.org The Susan G. Komen Breast Cancer Foundation

CBCRP’s Research Priority Issues

To be responsive and eligible for funding, each applicant must explain how their proposed research addresses one or more of our priority issues. The descriptions below are intended to cover broad breast cancer research topics and the examples provided are not all inclusive.

The Community Impact of Breast Cancer: the social context

Overview: What are factors that contribute to the unequal burden of breast cancer among diverse communities? Are there policy alternatives that would contribute to reducing disparities in access to prevention, detection, treatment, support, and/or survivorship services for California’s underserved populations? What is the influence of poverty, race/ethnicity, and environmental factors on breast cancer? What are the sociocultural, behavioral, and psychological issues of those affected by breast cancer and what services are needed to reduce the suffering caused by the disease? We encourage health policy; health services; and sociocultural, behavioral, and psychological research that address disparities and the burden of breast cancer among California’s diverse communities. Specific topics include:

• Health Policy
We encourage research examining the impact of public and private health policy on issues related to prevention, detection, and treatment of breast cancer as well as research into the formulation of policy alternatives that would reduce disparities related to prevention, detection, and treatment of breast cancer.

• Health Services
We encourage research examining the delivery of breast cancer-related services and how to most effectively deliver services, especially to the underserved.

• Sociocultural, Behavioral and Psychological Issues Relevant to Breast Cancer: The Human Side
We encourage research into the sociocultural, behavioral, and psychological issues of those affected by breast cancer or at high risk for the disease. Research that examines patient and practitioner interactions, enhancing quality of life, long-term survival, and participation in clinical research is encouraged, especially research addressing the needs of high-risk and underserved populations.

• Disparities: Eliminating the Unequal Burden of Breast Cancer
We encourage research that aims to reduce disparities in We encourage research that aims to reduce disparities in breast cancer incidence, morbidity, and mortality; access to prevention, treatment, and/or survivorship services based on factors related to race/ethnicity, socioeconomic status, geographic location, sexual orientation, ability, age, occupation, and/or other factors. Intervention research that reduces disparities is encouraged.

Etiology and Prevention: finding the underlying causes

Overview: What environmental and biological factors interact to increase the risk of developing breast cancer? What approaches can be used to reduce or eliminate breast cancer risk? We especially encourage new California-based studies that seek an understanding of the environmental and lifestyle causes of breast cancer, and how these increase risk and impact different communities in California. Specific topics include:

Etiology: The Role of Environment and Lifestyle
We encourage studies on breast cancer initiation that may be due to environmental exposures that subject women to agents that they, as individuals, cannot control. Other key topics of interest include breast cancer causes related to lifestyle (e.g., diet, exercise) and the underlying metabolic, hormonal, and environmental interactions. Studies on causative gene-environment interactions specific to breast cancer, especially those having the potential to lead to prevention strategies, are encouraged.

Prevention and Risk Reduction: Ending the Danger of Breast Cancer
Research exploring methods to prevent breast cancer or reduce risk, including elimination of external causative factors and the identification of surrogate markers for use in prevention trials are encouraged. Examples include nutritional factors, xenoestrogens, exercise, studies of genetic variation, and methods to modify known breast cancer genes and risk factors.

Biology of the Breast Cell: the basic science of the disease

Overview: Although basic science research in cancer is well-supported by other agencies, there remains a critical need to understand the pre-neoplastic, causative events of breast cancer at the tissue level, including the stroma. The genetic changes in disease progression and the tumor heterogeneity need clarification at the basic science level. Breast cancer stem cell research is especially encouraged. Specific topics include:

Biology of the Normal Breast:The Starting Point
Research should explore aspects of normal breast biology (e.g., aging) that are linked to the earliest stages of breast cancer, and which could provide insights into new approaches to prevent, detect, or treat the disease.

Pathogenesis: Understanding the Disease
Research must specifically focus on breast cancer tumor and stromal biology, including: (1) studies of relevant proteins and genes with an emphasis on their relationship to the actual disease, and (2) elucidating key cell signaling, growth control, cell cycle, and apoptosis pathways. We especially encourage new research on the process of metastasis and the development of tools and models to better understand the key metastatic events that impact patient survival.

Detection, Prognosis and Treatment: delivering clinical solutions

Overview: Clinical advances for breast cancer will utilize novel imaging technologies, new biomarkers, and genomic/proteomic approaches for more accurate diagnosis and prognosis. We encourage projects whose aims are on the critical path for translation. We support research into less toxic and more individualized therapies, mechanisms of drug resistance, and studies to evaluate alternative medicines and natural products. Specific topics include:

Imaging, Biomarkers, and Molecular Pathology: Improving Detection and Diagnosis
We encourage research into new, cost-effective technological and biological approaches for molecular imaging and new approaches for tumor analysis at the individual patient level. This includes advanced types of molecular classification, new biomarker development, and improved technologies for patient diagnosis and prognosis, especially using techniques to replace the current practice of screening mammography and biopsy.

Innovative Treatment Modalities: Search for a Cure
Promising leads from biology-based studies are encouraged to begin the critical path to clinical translation. Examples include immunotherapy, delivery technologies, gene therapy, new drug development/testing, and new approaches to clinical decision-making. Testing investigational anti-breast cancer agents for mechanism of action and identifying target patient populations are encouraged.

CBCRP Award Types

Community Research Collaboration Awards

Purpose/Requirements: The California Breast Cancer Research Program (CBCRP) believes that communities affected by breast cancer can take a leading role in research into the disease. Since 1997, our Community Research Collaboration (CRC) awards have funded community organizations—such as a breast cancer advocacy organization, community clinics, and other organizations serving women with breast cancer—to work in teams with well-trained, experienced research scientists. Together, the teams decide which breast cancer questions are most important to them, determine how to study these questions, gather and interpret data, and communicate findings to other community members, scientists, and the public. These teams have carried out sound and reliable research with results that can be applied to other communities. By combining the knowledge and interest of communities with the expertise and resources of research scientists, CRC teams are realizing the CBCRP’s vision of funding innovative and important research that will reduce the suffering caused by breast cancer.

We invite you to become part of this innovative, community-based participatory research by applying for a CRC award. More information about the CRC awards, including issues to consider and the types of projects we fund, can be found on our website at www.cabreastcancer.org/community/.

 

Two funding mechanisms are available:
The CRC Pilot award is for a maximum of $150,000 in direct costs for a period of up to 18 months. The Pilot award supports the initial phase of the project, which includes strengthening collaborations, developing feasible methods and tools, and collecting pilot data.
The CRC Full award is for a maximum of $600,000 in direct costs for a period of up to three years. The Full award funds projects with a fully developed research plan and supporting preliminary data, carried out by a well-integrated, experienced team of scientists and community members. Typically, a CRC Full application is for support of the completion of a research plan successfully carried out with a previous Pilot award.

For both types of CRC awards, indirect (F&A) costs are allowed for all institutions, except UC campuses.

Technical Assistance: Resources are available at the CBCRP to help CRC applicants with finding a partner, thinking through research ideas or partnership plans, and preparing applications for the CRC awards,  We will offer one-on-one assistance, teleconference workshops and an optional pre-application research plan review for those teams wishing to receive feedback prior to the actual application submission. Visit www.CABreastCancer.org//community/TechAssist.php or contact us at crcinfo@cabreastcancer.org to learn more about technical assistance opportunities.

Translational Research Awards

Purpose/Requirements: The CBCRP is committed to supporting research that is on a “critical path” for practical application.   Translational research to be supported by the CBCRP should have the potential for major impact in the areas of: (1) prevention, detection, diagnosis, ortreatment of breast cancer; (2) improved quality of life for survivors; (3) reduction in the community and social burden caused by the disease in California, or (4) advances in medical practices, health systems changes, health policies, or environmental modifications.  To distinguish "translational research" from other types of research funding, the CBCRP will require the applicant to present a "critical path" that maps how the project fits along a defined research continuum leading to practical applications. We welcome applicants from all disciplines, including: basic/clinical sciences, behavioral/social sciences, public health/community-based health sciences, and health policy. 

More information about the Translational Research Award, including its background, objectives, and criteria, can be found on our website: www.cbcrp.org/apply/aboutAwards.php.

Project Duration & Budget Caps: 3 years and $750,000 total direct costs. Indirect (F&A) costs are allowed for all institutions, except UC campuses.

To qualify for full application a “letter of intent” must be submitted by the deadline. The information presented in the LOI must:

• Describe the translational potential and impact specific to breast cancer in the designated research topic
• Focus on the study of human subjects. Support for projects using cell or animal models is not allowed
• Show evidence of PI qualifications for translational research and propose a project not fully supported by the PI’s other funding
• Involvement of advocates – Describe the role of advocates in the project design and implementation, and include any specific advocate involvement in past and current research by the applicant.  The CBCRP believes that research projects benefit by being directly informed by the experiences and knowledge of patient-survivors. Therefore, we expect breast cancer and community health advocates to be actively involved in the research we fund.

LOI decisions and invitations to submit a full grant application will be communicated to PIs by December 1, 2010.

Innovative, Developmental, and Exploratory Awards (IDEA)

Purpose/Requirements: To support speculative, exploratory, high-risk/high-reward projects with a primary focus on breast cancer. Applications for this award type should challenge existing paradigms, represent a new direction for the PI, and encourage innovation by the incorporation of techniques and approaches not yet well represented in mainstream breast cancer research. We encourage researchers to attempt breakthroughs that, if successful, could be leveraged into more substantial funding.  Both established researchers and new investigators (see below) are welcome to apply.

Examples of research not responsive to the IDEA are projects that: (1) propose incremental advances for the underlying topic, (2) duplicate the aims of completed or funded research to the PI derived from non-breast cancer studies without incorporating detailed breast cancer-specific justification, (3) overlap in topic and aims with current grant support to the applicant, or (4) represent portions of existing grants or are derived from cut-down larger, R01-type projects. To be maximally responsive to the IDEA funding mechanism, the applicant must either be previously trained and have published in breast cancer or collaborate with an established breast cancer researcher.  IDEA applicants are required to explain how the research project is on a “critical path” to substantially advance the topic under investigation.

IDEAs for new investigators: Researchers at a career level beyond postdoctoral training and less than three years as an independent investigator, or entering research from another field, are encouraged to apply for IDEA grants. During the peer review process, the applicant’s prior research history and accomplishments will be rated less stringently than for IDEAs from established investigators.

Project Duration & Budget Caps:

• 18 months maximum duration
• Budget cap for total project direct costs is either $100,000 or $150,000 (higher cap is for projects using animal or human subjects). Indirect (F&A) costs are allowed for all institutions, except UC campuses.

To qualify for full application, a Letter of Intent (LOI) must be submitted by the deadline. The information presented in the LOI must:

• Provide a brief background, rationale or purpose for the project specific to breast cancer in lay terms
• Describe a novel, innovative topic or approach for the proposed research that is linked to a CBCRP priority issue
• Explain how the project is a key portion of the “critical path” from basic knowledge, hypothesis-testing to a practical application specific to breast cancer at either the patient or community level
• Describe the role of advocates in the project (past, current, and proposed).  The CBCRP expects that research projects would benefit by being directly informed by the experiences of patient-survivors, so inclusion of representatives of established advocacy organizations (e.g., Y-ME, Komen, NBCC, patient support groups at medical and cancer cancers, etc.) is encouraged.

LOI decisions and invitations to submit a full grant application will be communicated to PIs by December 1, 2010.

►IDEA–competitive renewals

Purpose/Requirements: To allow for additional support for especially promising projects supported by recent CBCRP IDEA funding. To compete for a renewal, the PI must achieve expected milestones in the initial IDEA and satisfy proof-of-principle for the central topic under investigation. The competitive renewal IDEA submission will consist of a shorter application containing a progress report with revised aims. These will go though the same two-step process of peer and council review to qualify for funding.

Project Duration & Budget Caps:  Up to 2 years and $250,000.  Indirect (F&A) costs are allowed for all institutions, except UC campuses.

CBCRP Conference Awards

Purpose/Requirements/Budget: To inform, stimulate ideas, and foster research specific to breast cancer. Successful events will be designed to address one or more of the following goals:

• highlight resources particular to California
• encourage new collaborations
• recruit high quality researchers to the field
• examine and create solutions for disparities/inequities
• inspire paradigm-shifting research
• inform policy
• promote translational and/or outcome driven research

At least one major objective of the conference or event must focus on breast cancer and at least 50% of the event must be devoted to accomplishing the breast cancer objective(s).

Funding preference will be given to events that bring together people with different perspectives who do not usually meet and exchange views, and to events that are more likely to lead to new research projects and new collaborations.

Some format options for the Conference Award include: (1) a symposium with formal presentations and targeted breakout sessions, (2) a retreat that emphasizes less formal interactions, or (3) a conference style ‘roundtable’ discussion of pertinent issues without pre-existing leadership roles established. It is expected that researchers and, breast cancer advocates/activists, and the general public will be included in the meeting planning, organization and participation.

The event organizers must designate a specific use of the CBCRP funds (e.g. scholarships, a specific session or activity) and give the CBCRP name recognition for it in event materials. The requested budget can exceed the cost of the particular session or activity, but the additional items must also be distinguished from the overall budget. An awards banquet or reception is not appropriate for sponsorship. 

CBCRP staff must be included in the event planning and implementation and attendance by members of CBCRP staff and council must be permitted. The CBCRP will require a written report upon the completion of event activities within 60 days of the final meeting, and a fiscal report is due within 90 days.

Budget: Up to $25,000 in direct costs will be awarded. F&A (indirect) costs are not allowed. The CBCRP will distribute up to $50,000 in Conference Awards each year.

Evaluation and funding: Applications will consist of a conference plan (seven page limit with two additional pages for references) and supplementary forms. Applicants must list the major event objectives in the conference plan, identify the objectives that focus on breast cancer and describe how the event will accomplish the breast cancer objectives. The application will be evaluated based on the following criteria:
 

• Portion of the event that is focused on breast cancer (at least 50% of the event must be devoted to breast cancer objective(s) to be eligible for the award)
• Relevance of the major event objectives to the Conference Award goals
• Relevance of the event topic(s) to CBCRP research priority issues
• Strength of outreach to ensure representation from new disciplines, especially for disciplines not now integrated into breast cancer research
• Potential of the event to generate new ideas and facilitate collaboration
• The extent to which the activities that would be covered by the CBCRP funds are integral to the success of accomplishing the breast cancer objectives 
• Qualifications and background of the applicants/event organizers

The CBCRP’s council will evaluate Conference Award applications according to the criteria and make the funding decision. If an award is made, then it can take up to three months to disburse funds. Please contact Katherine McKenzie at conferenceaward@cabreastcancer.org or (888) 313-BCRP (2277) for questions.

Special Research Initiatives

Purpose/Requirements: Program-directed initiatives pursuing research strategies that increase knowledge about and create solutions to both the environmental causes of breast cancer and the unequal burden of the disease. Through the SRI, the CBCRP is leveraging California's unique and diverse geographic, population, and research resources to support critical studies that significantly move these fields forward. The CBCRP has been reserving 30% of annual research funds for the SRI since 2005. In 2010, the CBCRP council increased that set-aside to 50% and expanded the aims to include both population-level and targeted prevention strategies.

The SRI usesthree award mechanisms:

• Request for Qualifications (RFQs) tosolicit applications to identify the most qualified researcher to conduct studies with specific pre-determined research questions and plans.
• Program Directed Awards (PDAs) to fund crucial projects identified during the SRI strategy development proposed by the Steering Committee and approved by the CBCRP advisory council.
• Request for Proposals (RFPs) investigator-initiated applications, similar to our Core Funding, responding to a specific initiative topic.

The submitted RFPs and RFQs are reviewed and scored for scientific merit by out-of-state external reviewers to minimize possible conflicts of interest, and the final funding recommendations are made by CBCRP’s council. The Program Directed Awards are recommended to the CBCRP by the SRI Steering Committee and are programmatically reviewed by the Breast Cancer Research Council.

Funding opportunities for the Special Research Initiatives will be posted on our website when the information becomes available. Interested applicants are encouraged to contact sri@cabreastcancer.org to join the mailing list.

More information about the SRI aims and background is available on our website www.cabreastcancer.org/sri/.

Health Policy Initiative

Purpose/Budget: We will be allocating $150,000 annually for a rapid-response mechanism to fund health policy research issues as identified by the CBCRP council.
 
In March 2010, after three years of intense analysis, our Breast Cancer Research Council voted for a bold, new funding strategy to focus on CBCRP successes and California’s unique research opportunities. (Read our New Funding Strategy publication for more information).

Funding opportunities for the Health Policy Initiative will be posted on our website (www.cabreastcancer.org) when the information becomes available. Those interested in learning more as details as this Initiative develops are encouraged to contact healthpolicy@cabreastcancer.org to join the mailing list.

General Information

Note the following eligibility requirements and conditions for receiving grant support from the CBCRP.

Who May Apply

Conditions of Awards

1. Any individual or organization in California may submit an application. The research must be conducted primarily in California. We welcome investigators from community organizations, public or privately-owned corporations and other businesses, volunteer health organizations, health maintenance organizations, hospitals, laboratories, research institutions, colleges, and universities. 2. We encourage researchers new to breast cancer to apply. We recommend that applicants who have limited experience in scientific research or in scientific grant-writing collaborate with established breast cancer researchers in order to maximize specificity and impact on breast cancer. 3. Re-submissions and previously funded PIs: Any resubmission for IDEA and Translational Research Awards must go through the LOI process. The CRC awards are open to re-submission from any previous grant cycle. Previously-funded PIs are eligible to apply for new projects with distinct aims from the previous CBCRP grants. 4. IDEA–competitive renewal eligibility: Recipients of CBCRP IDEA grants having received initial funding disbursements in 2009-2010 (Cycle 15 only).     5. Multiple applications and grant limits: A PI may submit more than one application, but each must have unique specific aims. For Cycle 17, a PI is limited to a maximum of two (2) grants either as PI or co-PI, and these must be in different award types.

1. All grant recipients must satisfy the standard requirements for receiving an award or modified requirements, if appropriate, as determined by the University of California. These requirements include fiscal management, accounting practices, liability insurance, bonding, indemnification of the UC Regents, non-discrimination in employment, and assurances regarding the treatment of animal or human subjects. Applicants do not have to meet these requirements at the time an application is reviewed, but no grant will be awarded until they are satisfied. Also, before an award is disbursed, a prospective grant recipient must satisfy certain stipulations (see application information packet). The CBCRP staff will provide information to assist prospective recipients in satisfying these stipulations. 2. Grant recipients are required to attend the 2013 CBCRP Research Symposium and must include travel costs for this in the grant budget. In addition, grant recipients may be asked to present their work at other CBCRP-related functions. 3. Intellectual Property: CBCRP does not retain rights to a funded grant’s intellectual property.  Patentable inventions or discoveries conceived or reduced to practice shall belong to the grant recipient.  Copyright works are the property of the recipient. Other discoveries made or reduced to practice which may not be protected by patent or copyright, such as biological materials, plasmids, and cell lines, remain the property of the recipient to be licensed in the public interest. The recipient shall use reasonable efforts to achieve expeditious practical application of the patents, copyrights, and tangible research results.